| Product Name | Rabbit anti-MYC polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Tags Antibodies |
| Antigen Alias | MRTL, c-Myc, bHLHe39 |
| Immunogen | The immunogen for anti-MYC antibody: synthetic peptide directed towards the N terminal of human MYC |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| Species Reactivity | BovineDogGuinea PigHumanMousePigRabbitRatSheep |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | MYC |
|---|---|
| Gene Synonyms | MRTL c-Myc bHLHe39 |
| Gene Full Name | V-myc myelocytomatosis viral oncogene homolog (avian) |
| Gene Summary | MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. |
| Alternative Names | MRTL c-Myc bHLHe39 |
| Molecular Weight(MW) | 19kDa |
| Sequence | 170 amino acids |
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Data sheet for OM108597