The protein encoded by this gene belongs to the ARL
(ADP-ribosylation factor-like) family of proteins, which are
structurally related to ADP-ribosylation factors (ARFs). ARFs,
described as activators of cholera toxin (CT)
ADP-ribosyltransferase activity, regulate intracellular vesicular
membrane trafficking, and stimulate a phospholipase D (PLD)
isoform. Although, ARL proteins were initially thought not to
activate CT or PLD, later work showed that they are weak
stimulators of PLD and CT in a phospholipid dependent manner.1) Houghton, F.J., et al. Cell 138(4):787-794(2009)
Immunogen
This ARL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-108 amino acids from the Central region of human ARL1.
Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.