Immunohistochemical
Colon, submucosal plexusWestern blot
Host: Rabbit Target Name: NR3C1 Sample Tissue: Hela Antibody Dilution: 1.0ug/ml| Product Name | Rabbit anti-NR3C1 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GCCR, GCR, GR, GRL |
| Immunogen | The immunogen for anti-NR3C1 antibody: synthetic peptide directed towards the N terminal of human NR3C1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineGuinea PigHorseHumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NR3C1 |
|---|---|
| Gene Synonyms | GCCR GCR GR GRL |
| Gene Full Name | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| Gene Summary | NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. |
| Alternative Names | GCCR GCR GR GRL |
| Molecular Weight(MW) | 86kDa |
| Sequence | 777 amino acids |
Immunohistochemical
Colon, submucosal plexus
Western blot
Host: Rabbit Target Name: NR3C1 Sample Tissue: Hela Antibody Dilution: 1.0ug/ml| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Data sheet for OM112159