Western blot
Host: Rabbit Target Name: AVPR2 Sample Tissue: Human Fetal Heart Antibody Dilution: 1.0ug/mlWestern blot
Host: Rabbit Target Name: AVPR2 Sample Tissue: Human Fetal Lung Antibody Dilution: 1.0ug/mlWestern blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate| Product Name | Rabbit anti-AVPR2 polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ADHR, DI1, DIR, DIR3, MGC126533, MGC138386, NDI, V2R |
| Immunogen | The immunogen for anti-AVPR2 antibody: synthetic peptide directed towards the C terminal of human AVPR2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigMouseSheep |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | AVPR2 |
|---|---|
| Gene Synonyms | ADHR DI1 DIR DIR3 MGC126533 MGC138386 NDI V2R |
| Gene Full Name | Arginine vasopressin receptor 2 |
| Gene Summary | This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. |
| Alternative Names | ADHR DI1 DIR DIR3 MGC126533 MGC138386 NDI V2R |
| Molecular Weight(MW) | 40kDa |
| Sequence | 371 amino acids |
Western blot
Host: Rabbit Target Name: AVPR2 Sample Tissue: Human Fetal Heart Antibody Dilution: 1.0ug/ml
Western blot
Host: Rabbit Target Name: AVPR2 Sample Tissue: Human Fetal Lung Antibody Dilution: 1.0ug/ml
Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Data sheet for OM118070