Application
TRAF3 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TRAF3 antibody detected the TRAF3 protein (arrow).Application
TRAF3 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the TRAF3 antibody detected the TRAF3 protein (arrow).| Product Name | TRAF3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRAF3; CAP1; CRAF1; TNF receptor-associated factor 3; CAP-1; CD40 receptor-associated factor 1; CD40-binding protein; LMP1-associated protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CAP1 CRAF1 |
|---|---|
| Alternative Names | TRAF3 CAP1 CRAF1 TNF receptor-associated factor 3 CAP-1 CD40 receptor-associated factor 1 CD40-binding protein LMP1-associated protein 1 |
| Molecular Weight(MW) | 64490 Da |
| Function | Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14 |
| Tissue Specificity | This TRAF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-517 amino acids from the C-terminal region of human TRAF3. |
| Cellular Localization | Cytoplasm (Probable). Endosome (By similarity). Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus |
| Entrez Gene | 7187 |
|---|---|
| Nucleotide Accession | NP_663777.1 NP_663778.1 NP_003291.2 |
Application
TRAF3 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TRAF3 antibody detected the TRAF3 protein (arrow).
Application
TRAF3 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the TRAF3 antibody detected the TRAF3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Data sheet for OM223506