Angiopoeitin-1 (Ang-1) and Angiopoietin-2 (Ang-2) have importance in the development of the endothelium by regulating tyrosine phosphorylation of the membrane receptor Tie-2/Tek. Ang-1 binding to Tie-2/Tek causes phosphorylation of the receptor. Ang-2 competes for this binding, and thus blocks receptor phosphorylation. Ang-1 has a potential fibrinogen-like domain at the carboxyl terminus and coiled-coil regions in the amino terminus. Ang-1 is prominently expressed in the myocardium of atrium and ventricle, mesenchymal and smooth muscle cells surrounding most blood vessels, and lung. In the adult, Ang-1 is also expressed in the heart and liver.
Immunogen
Angiopoietin - 1 antibody was raised against amino acids 21-40 from the C-Terminus of Angiopoietin - 1 (Mouse).
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAIHCWB
Angiopoietin-1 antibody can be used in ELISA starting at 1 μg/mL, Western Blot starting at 1 μg/mL, and immunohistochemistry starting at 10 μg/mL.: