The WNT gene family consists of structurally related genes
which encode secreted signaling proteins. These proteins have been
implicated in oncogenesis and in several developmental processes,
including regulation of cell fate and patterning during
embryogenesis. This gene is a member of the WNT gene family. It is
overexpressed in cervical cancer cell line and strongly coexpressed
with another family member, WNT10A, in colorectal cancer cell line.
The gene overexpression may play key roles in carcinogenesis. This
gene and the WNT10A gene are clustered in the chromosome 2q35
region. The protein encoded by this gene is 97% identical to the
mouse Wnt6 protein at the amino acid level.1) Wang, C., et al.Endod 36(2):238-243(2010)
Immunogen
This WNT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-201 amino acids from the Central region of human WNT6.
Western blot analysis in HepG2 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.