Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.1) Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661 (2009)
Immunogen
CD11c antibody was raised against a peptide sequence around aa.1155~1159 (Q-T-P-S-P) derived from Human CD11c.