This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Molecular Weight(MW)
38 kDa
Source
Rabbit
Cellular Localization
Cell membrane
Application
WB
Western blot analysis using CD86 antibody against HEK293(1), PANC-1 (2),MCF-7(3) cell lysate.
IHC
Immunohistochemical analysis of paraffin-embedded stomach cancer tissues using CD86 antibody with DAB staining.
Application Notes
WB:1:200-1:2000 IHC:1:200-1:1000
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.